General electives can be selected from all the courses offered at Koç University.

HSRB 501 / FEMALE AND MALE REPRODUCTIVE SYSTEMS: ANATOMY, HISTOLOGY AND DEVELOPMENT
Sınıf: Credit: 4Precondition:

The structure of male and female reproductive systems at macroscopic and microscopic levels. Formation of the organs during the development of a human embryo. Lectures will be complemented by laboratory work.

HSRB 502 / CELL CULTURE
Sınıf: Credit: 3Precondition:

Theoretical and practical aspects of working in a cell culture laboratory. Maintenance of a cell culture laboratory; problems and solutions.

HSRB 503 / ASSISTED REPRODUCTIVE TECHNOLOGIES AND IN VITRO FERTILIZATION
Sınıf: Credit: 4Precondition:

The definition of infertility. The treatment strategies and drugs used to treat infertile couple during an ART cycle. Treatment strategies in assisted reproduction for special populations such as low responder patients, women with endometriosis and PCOS. The definition of recurrent implantation failure. The indications of fertility preservation and the strategies used to treat these patients. The complications of ART treatment.

HSRB 504 / EMBRYOLOGY AND ANDROLOGY LABORATORIES: BASIC PRINCIPLES AND APPLICATIONS
Sınıf: Credit: 4Precondition:

The definition of ART. How to set up an IVF lab. The workflow and manipulations in ART. The evaluation of success in ART-evaluation of fertilization, embryo quality, early embryogenesis and implantation. The problems that affect success of ART. The evaluation and management of problems related to ART.

HSRB 505 / STEM CELLS
Sınıf: Credit: 2Precondition:

Stem cells, which have potential to develop into many different cell types. Recent studies related to these cells. Clinical importance and laboratory applications.

HSRB 506 / PLACENTA AND FETAL MEMBRANES
Sınıf: Credit: 2Precondition:

Placenta and fetal membranes (amniochorionic membranes) are one of the most important tissues in the intrauterine cavity that are vital for the safeguarding of the fetus, endurance of pregnancy, and as a signaler to introduce parturition. This course aims to learn the structure, biology, life cycle and functions of the placenta and fetal membranes by relating them to their pathology and possible outcomes to the newborn.

HSRB 507 / EMBRYOGENESIS
Sınıf: Credit: 2Precondition:

Fertilization of an oocyte (female germ cell) by a sperm (male germ cell) and development of an embryo from zygote. Formation of the human body.

HSRB 508 / CELL DIVISION AND GAMETOGENESIS
Sınıf: Credit: 2Precondition:

Multiplication of cells, different stages of mitosis and meiosis, changes at the cell structure during division. Formation of male gametes (sperms) and female gametes (oocytes) will be discussed comparatively.

HSRB 509 / BIOSTATISTICS
Sınıf: Credit: 3Precondition:

Statistical science and its application to problems of human health. The lectures will primarily focus on problems related to reproductive biology. Use of suitable statistical tests, correct interpretation of data, correct and effective presentation of results will be comparatively examined and discussed with statistical work presented in leading reproductive biology journals. Lectures will be complemented with lab work.

HSRB 510 / RESEARCH ETHICS
Sınıf: Credit: 1Precondition:

Ethical considerations related to reproductive biology with a specific focus on human cell and human tissues. How to collect human cells (granulosa cells, gametes, ovarian/testicular tissues, ...), how to design consent forms and manage relation with patients to avoid ethical problems will be discussed. Ethical issues while using mouse cells-especially embryos will also be considered. The rules, regulations and guidelines in various leading countries will be comparatively discussed with the rules in our country.

HSRB 512 / EMBRYOLOGY AND ANDROLOGY LABORATORIES: BASIC PRINCIPLES AND APPLICATIONS
Sınıf: Credit: 4Precondition:

This course mainly aims to build up a perspective of a proper IVF lab, particularly embryology and andrology labs, and will include the following topics; i) how to set up an IVF lab, ii) maintaining stability and quality control in the lab, iii) basic principles of work-flow in an embryology lab, iv) basic principles of work-flow in an andrology lab, v) accreditation of an IVF-lab and international aspects, vi) overview of the applications in an IVF lab, vii) legal aspects in the IVF-lab.

HSRB 590 / SEMINAR
Sınıf: Credit: 0Precondition:

This course is non-credit and aims to increase the scientific interaction between students and improve their presentation skills with the participation of students from all interdisciplinary programs. The Seminar course which is consisting of presentation of the studies and researches in front of the community within the framework of the techniques determined with the guidance of the advisor, and question and answer part are graded each semester.

HSRB 595 / MS THESIS
Sınıf: Credit: 0Precondition:

This course is non-credit course which the supervisor evaluates the student's thesis work. It covers all the studies and researches to be carried out on the thesis subject determined by the guidance of the advisor and is graded each semester by the advisor.

RPSP 601 / MOLECULAR REPRODUCTIVE ENDOCRINOLOGY
Sınıf: Credit: 3Precondition:

Reproductive endocrinology is a branch of science that involves endocrinologic aspect of gonadal function in both sexes and reproduction. Better understanding of molecular mechanisms underlying reproductive disorders and the application of problems of human reproduction especially endocrinological problems are important. This lecture will enable students to develop broad vision on molecular aspects of reproductive endocrinology and will allow in depth study of current aspects of reproduction.

RPSP 602 / REPRODUCTIVE IMMUNOLOGY&GENETIC
Sınıf: Credit: 3Precondition:

This course will provide an up-to-date overview on reproductive genetics and immunology varying from very fundamental aspects of genetics to most-complicated genetic analysis tools and their application to certain reproductive disorders and prenatal diagnosis. In addition to genetics, there will be comprehensive lectures on the immunology of reproduction at implantation, early pregnancy and certain commonly seen benign reproductive disorders and recurrent abortions. Moreover, immune editing and immune escape mechanisms in benign and malignant disorders of the reproductive system will be reviewed.

RPSP 603 / REPRODUCTIVE IMMUNOLOGY & GENETICS
Sınıf: Credit: 3Precondition:

This course will provide an up-to-date overview on reproductive genetics and immunology varying from very fundamental aspects of genetics to most-complicated genetic analysis tools and their application to certain reproductive disorders and prenatal diagnosis. In addition to genetics, there will be comprehensive lectures on the immunology of reproduction at implantation, early pregnancy and certain commonly seen benign reproductive disorders and recurrent abortions. Moreover, immune editing and immune escape mechanisms in benign and malignant disorders of the reproductive system will be reviewed.

RPSP 690 / PhD SEMINAR COURSE
Sınıf: Credit: 0Precondition:

This course is non-credit and aims to increase the scientific interaction between students and improve their presentation skills with the participation of students from all interdisciplinary programs. The Seminar course which is consisting of presentation of the studies and researches in front of the community within the framework of the techniques determined with the guidance of the advisor, and question and answer part are graded each semester.

RPSP 695 / PHD THESIS
Sınıf: Credit: 0Precondition:

This course is non-credit course which the supervisor evaluates the student's thesis work. It covers all the studies and researches to be carried out on the thesis subject determined by the guidance of the advisor and is graded each semester by the advisor.

IMMN 501 / BASIC CONCEPTS OF IMMUNOLOGY
Sınıf: Credit: 3Precondition:

The aim of this course is to introduce the recognition of antigen, its role and role of MHC, immune receptors and signaling pathways, development of lymphocytes, adaptive immune system principles, mechanisms of effector immune responses, newly defined cells and signaling pathways and new developments in immunology. Students will prepare a presentation for scheduled topic. The assessment of the students will be done according to their final examination and performances in presentations and participation to scientific discussion.

IMMN 502 / FUNDAMENTAL IMMUNOLOGY
Sınıf: Credit: 3Precondition:

Introduce the recognition of antigen, its role and role of MHC, immune receptors and signaling pathways, development of lymphocytes, adaptive immune system principles, mechanisms of effector immune responses, newly defined cells and signaling pathways and new developments in immunology.

IMMN 503 / IMMUNE SYSTEM IN HEALTH&DISEASE
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

The aim of this course is to teach the principles of the immune system in detail in health and disease immunology and to explain the immunological mechanisms in detail. Specialized topics such as infection immunology, allergy, hypersensitivity responses, immunodeficiencies, transplantation immunology, autoimmunity mechanisms, and tumor immunology will be discussed. Students will prepare a presentation for each scheduled topic and the lesson will be interactive with the discussion of each topic.

IMMN 504 / ADVANCE CLINICAL IMMUNOLOGY
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

This course aims to provide students with knowledge and understanding of the role of immunological mechanisms in the development and treatment of diseases. Clinician-scientists will explain the course, and the topics will be covered through diseases that are their research areas. The topics will be handled interactively with new literature. Students will be assessed based on their final exams and their performance in presentations and their participation in the scientific discussion.

IMMN 505 / INFECTION&IMMUNITY
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

This course aims to explain the immunological mechanisms involved in the pathogenesis of infections and pathogen-related virulence factors, the molecular epidemiology of infections and the mechanisms of resistance to antimicrobial therapies. The course will be interactive with a predominantly focused education model and will be supported by discussions of articles on the agenda.

IMMN 506 / ALLERGY&HYPERSENSITIVITY REACTIONS
Sınıf: Credit: 3Precondition: IMMN 501 and IMMN 502

Basic and specific allergic immune mechanisms like interaction of environmental & genetic factors, epithelial barrier function, Innate and adaptive immunity cells, tolerance mechanisms, airway inflammation in asthma and allergic rhinitis, IgE /non-IgE-mediated inflammation in food & drug allergy, skin inflammation in eczema, urticaria.